In the present study we have prepared bilayer matrix of atorvastatin immediate release and atenolol sustained tablet. Atorvastatin immediate release matrix composed of high amount of starch while Atenolol sustained contains high amount of Kollidon SR and MCC pH 102 which may be possible reason for sustained drug release. The in-vitro drug release of prepared bilayered tablet (FT) was measured and compared with marketed tablet of sustained release atenolol tablet (NOLWIS; Smayan Healthcare Pvt Ltd) which showed fast release of atorvastatin within 45 seconds and sustained release of atenolol over a period of more than 24 hrs. However, the marketed tablet showed complete drug release within 14 hrs. These results revealed that the prepared bilayer tablet have fast releasing ability of atorvastatin and sustained release profile of atenolol.
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